What Is Rejuran Healer? Salmon DNA (PN) Injections Explained
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Quick answer: Rejuran Healer is a Korean skin booster that contains polynucleotides (PN), purified DNA fragments derived from salmon. It is injected in many small deposits into the skin to support repair, improving texture, hydration, fine lines and overall skin condition over a series of sessions. It does not add volume or lift like filler, and temporary bumps for a day or two are normal.
What is Rejuran Healer?
Rejuran Healer is made by PharmaResearch, a Korean pharmaceutical company focused on regenerative medicine. It is approved in Korea as an injectable for skin rejuvenation and is used for concerns such as dull or rough texture, dryness, fine lines and sensitive skin. The brand also includes related products for specific areas, such as under the eyes and acne scars.
The manufacturer uses a patented process it calls DOT technology to purify and size the DNA fragments. The result is a gel that is injected into the dermis, the layer of skin that contains collagen.
What are polynucleotides, and why salmon DNA?
Polynucleotides are chains of nucleotides, the building blocks of DNA. Salmon DNA is used because it can be purified at scale, and the purified fragments are designed to be biocompatible with human tissue. The product does not contain fish protein in the way food does, but anyone with a fish allergy should tell their doctor before treatment.
Research suggests PN may support the skin's own repair processes, including fibroblast activity, collagen production and tissue hydration, and may have anti-inflammatory effects. Much of the evidence comes from small clinical studies and laboratory work, so larger long-term trials are still needed.
What can Rejuran Healer help with?
- dull, tired-looking or rough skin
- dryness and a weakened skin barrier
- fine lines and early loss of elasticity
- enlarged pores and uneven texture
- sensitive or reactive skin, and recovery after laser or other energy treatments
It is not designed to fill deep wrinkles, restore lost volume or lift sagging skin. Those concerns usually need other treatments.
How is Rejuran Healer injected?
- Numbing: anesthetic cream is applied for about 30 to 60 minutes, because PN injections can sting.
- Injection: the doctor places many small deposits into the dermis across the face, by hand or with an injector device.
- Afterwards: small raised bumps are visible at each point. A soothing mask or cooling may be applied.
The injection part usually takes 15 to 30 minutes for the full face.
How many sessions do you need?
Rejuran works best as a series. An expert review of polynucleotide treatment describes a typical rejuvenation protocol of three sessions spaced about four weeks apart, with maintenance afterwards based on how the skin responds. Some people return every few months, others once or twice a year.
When will I see results?
Some people notice that their skin feels more hydrated and looks smoother within a couple of weeks of the first session. Changes in texture, elasticity and fine lines usually build over the course of the series. Results vary with age, skin condition, sun habits and skin care.
What are the side effects and downtime?
Downtime is usually short, but you may look a little bumpy for a day or two. Common, temporary effects include:
- small raised bumps at injection points, usually flattening within one to two days
- redness and mild swelling
- small bruises, which can take up to a week or so to fade
- tenderness for a day or two
Less common risks include infection, prolonged lumps and allergic reactions. Seek medical advice if you have increasing pain, spreading redness, pus or fever.
Who should avoid Rejuran Healer?
Tell your doctor if you are pregnant or breastfeeding, have a fish or salmon allergy, have an active skin infection or cold sores in the area, or take blood thinners. Your doctor will decide whether treatment is suitable.
Aftercare tips
- Do not press, rub or massage the bumps.
- Skip makeup until the next day or as your clinic advises.
- Avoid saunas, hot baths, intense exercise and alcohol for at least a day.
- Use a gentle cleanser, a simple moisturizer and broad-spectrum sunscreen.
- Hold off on retinoids, acids and scrubs for a few days.
If you are visiting Korea, try to schedule Rejuran early in your trip so bumps have time to settle before flights or photos, and so you can contact the clinic if you have any concern. Bring a record of the product and the date of treatment home with you in case you continue the series elsewhere.
Frequently asked questions
Is Rejuran Healer the same as PDRN?
Both are derived from salmon DNA. PN products like Rejuran contain longer DNA chains and form a gel, while PDRN is generally a shorter-chain form. The terms are sometimes used loosely, so ask what product is being used.
Does Rejuran Healer hurt?
It is often described as more stinging than some other boosters. Numbing cream makes it tolerable for most people.
Can I wear makeup after Rejuran?
Most doctors advise waiting at least until the next day so the injection points can close. Follow your clinic's instructions.
Can Rejuran be combined with laser treatments?
Yes. It is often combined with lasers or other devices, and the timing should be planned by your doctor.
This article is for general information and does not replace a consultation with a doctor. Results and suitability vary from person to person.
Sources: PharmaResearch: Rejuran; Dove Medical Press: Polynucleotides in aesthetic practice (review)
